Toll Like Receptors Signaling in Inflammatory Bowel Disease-Are They New Targets of the Future?
Volume 13 ; Issue 1 ; in Month : (2021) Article No : 120
Kumar PV, Palatty PL, Achuthan CR
Abstract
Inflammatory bowel disorder is related to situations ulcerative colitis and Crohn’s disorder; however, its motive is unknown and the infection may be because of changing of intestine homeostasis with innate immunity performs a crucial position in spotting pathogens, hence keeping intestinal homeostasis. In 1985, Christiane Nüsslein-Volhard and Eric Wieschaus named it toll-like receptors because of the toll gene recognized in Drosophila. Toll-like receptors are known for their homeostasis of the immune system. The toll-like receptors from one to thirteen are expressed in humans and mice. Toll-like receptors signalling pathways are the myeloid differentiation factor 88-dependent pathway and TIR-domain-containing adapter-inducing interferon-β-dependent pathway, ends in the induction or suppression of inflammatory response. It is important to keep homeostasis in the intestine and targeting toll-like receptor signalling has been a challenge, in treating many diseases. With new emerging nano-inhibitors, small molecule inhibitors, oligonucleotide, lipid- analogs, microRNAs that inhibits TLR signalling, to control excessive inflammation can we expect a new ray of hope emerging in the future?
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