Volume 18 ; Issue 1 ; in Month : 2025 (2025) Article No : 133
Amol W There

Abstract

In preclinical research, the laboratory animals are used to study the pharmacokinetics, pharmacodynamics, and Toxicity of the drugs. These studies are generally assessed in blood, plasma or serum metrices. Whole blood with and without anticoagulant are collected from small animals like rat or mouse by withdrawal technique to study a drug PK profiling, biochemical parameters and hematology assay. Hence, the plasma and serum are separated from the anticoagulated blood and coagulated blood, respectively, by the centrifugation technique under refrigerated temperature. Further, the storage conditions, if analysis delayed, for plasma and serum samples must be specified. Thus, the objective of the review is to demonstrate the fundamental and pragmatic understanding about the collection of blood samples from the animal species, precise handling of blood samples, use of centrifugation machine for matrix separation, and sample storage conditions.

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