]> Neha Tyagi, Santosh K Verma and Ajeet Volume 10 Issue 1 2231-5896 10.31531/2231-5896.1000101 This paper reviews model advances in epilepsy in recent years Epilepsy is the commonest serious neurological condition with a prevalence of 051 and Epilepsy is a chronic neurological condition characterized by recurrent seizures Use of appropriate animal models is essential because epileptogenesis and seizure generation in temporal lobe epilepsy and other forms of epilepsy cannot be fully acquired in clinical studies with humans Seizures are a combination of electrical and behavioral events that can induce chemical molecular and anatomic alterations In this review we summarize the most frequently used models of chronic epilepsy and models of acute seizures induced by electrical and chemical kindling Kindling is animal models of epilepsy induced by electrical stimulation of the brain Seizures are induced with minimal neuronal damage which could greatly enhance our ability to define the basis for the initiation and remission of spontaneous seizure Various animal models are also critical for elucidating the mechanisms underlying neurologic dysfunctions induced by developmental alcohol exposure and for uncovering the evolutionarily conserved mechanisms of epileptogenesis All Published Work is Licensed under a creative commons attribution 4.0 international license 2024