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<title>Internationale-Pharmaceutica-Sciencia-ISSUE VOLUME Volume 16 ISSUE Issue 1</title>
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Internationale-Pharmaceutica-Sciencia: VOLUME Volume 16 ISSUE Issue 1, 2023 2023
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<title>Internationale-Pharmaceutica-Sciencia-ISSUE VOLUME Volume 16 ISSUE Issue 1</title>
<link>http://ipharmsciencia.edwiserinternational.com/rss-feed.php</link>
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		<title>Development-and-Evaluation-of-Ranitidine-Floating-Tablet-for-Ulcer-Healing-and-Soothing</title>
		<pubDate>28-Sep-2023</pubDate>
<link>http://ipharmsciencia.edwiserinternational.com/admin/uploads/Hr0EG2.pdf</link>
		<author>Nirala-N-Choudhary-RK-Dasgupta-D-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[In this current work floating tablets of ranitidine and aloe vera was prepared. The objective behind the work was to develop a formulation of H2 antagonist in collaboration with aloe vera to produce an ulcer soothing and ulcer protective effect. Ranitidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. The effective treatment of erosive esophagitis requires administration of 150 mg of Ranitidine, four times a day. A conventional dose of 150 mg can inhibit gastric acid whereas aloe vera will produce ulcer soothing affect and laxative effect too. In- vitro buoyancy studies were performed for all the ten formulations as per the method described by Rosa et al. The randomly selected tablets from each formulation were kept in a 100ml beaker containing simulated gastric fluid, pH 1.2 as per USP. The time taken for the tablet to rise to the surface and float was taken as floating lag time (FLT).]]>}</description>
		</item><item>
		<title>Calibration-of-Medical-Devices-Method-and-Impact-on-Operation-Quality</title>
		<pubDate>28-Sep-2023</pubDate>
<link>http://ipharmsciencia.edwiserinternational.com/admin/uploads/ArGS1H.pdf</link>
		<author>Kumar-R-Choudhary-RK-Archana-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Medical devices play a pivotal role in modern healthcare, aiding in accurate diagnosis, monitoring, and treatment of patients. The reliability and accuracy of these devices are indispensable for ensuring patient safety and well-being. This project highlights the critical importance of calibrating medical devices to maintain their accuracy, precision, and performance, ultimately safeguarding the lives of patients. Calibration of medical devices is a systematic process that verifies and adjusts their measurements to a known standard. This process ensures that medical devices consistently provide accurate data and results. In the absence of proper calibration, there is a significant risk of incorrect readings, misdiagnoses, and inappropriate treatment plans, all of which can lead to patient harm. Regular calibration is essential not only for maintaining patient safety but also for meeting regulatory requirements and quality assurance standards. It helps identify and rectify deviations or drifts in device performance, preventing potential hazards in healthcare settings. Compliance with calibration protocols ensures that medical institutions and professionals can deliver reliable and effective care. Moreover, calibrated medical devices enhance the efficiency and cost-effectiveness of healthcare systems by minimizing the need for repeated tests and procedures due to inaccurate results. Patients can have confidence in the reliability of the devices used in their care, fostering trust in healthcare providers and institutions.]]>}</description>
		</item><item>
		<title>Formulation-and-Evaluation-of-Cetrimide-Based-In-situ-Gelling-System-for-Ocular-Drug-Delivery</title>
		<pubDate>04-Nov-2023</pubDate>
<link>http://ipharmsciencia.edwiserinternational.com/admin/uploads/UBJVyT.pdf</link>
		<author>Abhishek-Kumar</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Conventional drug delivery system is a traditional type of drug delivery system which manifests poor bioavailability of drug due to tear turn over, tear flow and blinking of eye which causes removal of drug at the ocular surfaces. To overcome from the drawbacks of conventional drug delivery system In- situ gels come into the fashion of ocular drug delivery system for the treatment of ocular diseases which have enhanced bioavailability and better for patients compliance. The goal of the present work to express formulation and evaluation of cetrimide in situ gels which have anti-fungal activity used in the treatment of fungal keratitis caused by Fusarium solani. Carbopol 934 is used as viscosity enhancing property. Xanthan gum was used as thickening and stabilizing agent. Sodium alginate was used for gelation ability. The combination of carbopol and xanthan gum showed good gelling capacity and gelation time up to 6hrs period. The developed formulation of cetrimide in situ gels was stable non -irritant which are feasible substitute for conventional drug delivery system such as eye drops by virtue of its stability to increase residence time of drug at the ocular surfaces and provide sustained release of drug with increase bioavailability and better for patients compliance.]]>}</description>
		</item><item>
		<title>Formulation-and-Evaluation-of-Azithromycin-Dihydrate-Based-In-situ-Gel-as-Floating-Drug-Delivery-System</title>
		<pubDate>04-Nov-2023</pubDate>
<link>http://ipharmsciencia.edwiserinternational.com/admin/uploads/FMgV90.pdf</link>
		<author>Vikash-Kumar-and-Neha-Sharma</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Floating Drug Delivery Systems have been used to overcome some of the problems like low oral absorption of drugs with narrow absorption window as it has an advantage of sustained release of drugs over a prolonged period of time. In-situ gels are the novel approach in the context of floating drug delivery systems. The aim of this present study was to develop an oral stomach specific floating in-situ gel of Azithromycin dihydrate. In-situ gelling system was prepared by dissolving different concentrations of polymers like sodium alginate, xanthan gum in the de-ionized water already prepared with sodium citrate at 60C to 90C. After the heating with continuous stirring the formulation was cooled below the temperature of 40C with the addition of certain amount of drug and calcium carbonate which acts as gas generating agent. All the formulations showed pH in the range of 6.1 to 6.7, drug content was found to be in the range of 97.29% to 99.27%. Floating lag time was less than 1 minute for all the formulations and the duration of floatation was more than 24 hours for the combination of polymers. Appearance and measurement of water uptake by the gel was also good. Stability studies were also done and was found to be at normal phase at different temperatures and at interval of times. Although, F9 showed the maximum properties of an in-situ gel with increased gastric retention time with low slowly release of the drug. Drug release was found to be decreasing as the concentration of polymer increases. However, it was concluded that the in-situ gelling system of Azithromycin dihydrate could be prepared in various concentrations of different polymers and the combination of polymers to increase the patient compliance and reduction in the frequency of dosing of the drug with the increased gastric residence time for the drug in the stomach.]]>}</description>
		</item><item>
		<title>Development-and-Evaluation-of-Polyherbal-Formulation-with-Carminative-Effect</title>
		<pubDate>04-Nov-2023</pubDate>
<link>http://ipharmsciencia.edwiserinternational.com/admin/uploads/EBnp8R.pdf</link>
		<author>Ritika-Verma-and-Neha-Sharma</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Carminative drugs, which reduce or prevent gastrointestinal flatulence and colic and have historically been used to enhance human health, is examined in this study. The carminative qualities of spices like clove, coriander, cardamom, fennel, nutmeg, black pepper, and ajowan are highlighted in particular. Numerous health benefits, including anti-inflammatory, antiseptic, anti-hypertensive, and myorelaxant qualities, are demonstrated by these spices. To enhance their effects, formulations were made utilizing a geometrical approach and different weights of these powders were combined and evaluated. To confirm the quality and safety of the carminative powder, organoleptic evaluation, physicochemical characteristics, rheological evaluation, and carminative potential were evaluated. The carminative powder, had a pH of 6.5, is free-flowing, non-sticky, and aesthetically pleasing, according to the results. Given the rising popularity of natural treatments and holistic healthcare, the future of carminative herbal medications is bright. Due to their digestive advantages, many herbs and mixtures have grown in popularity, and this pattern is predicted to continue. New carminative herbs and novel formulations may be found as a result of research and development in herbal medicine in the upcoming years. The market for carminative herbal medicines is projected to grow as consumer interest in plant-based treatments for digestive problems rises.]]>}</description>
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