A Concise Review on Methods of Solubility Enhancement
Volume 11 ; Issue 1 ; in Month : (2020) Article No : 109
Godase CB, Babar AL, and Gopal AB
Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this process may occur not only because of dissolution but also because of a chemical reaction. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% of new chemical entities developed in pharmaceutical industry are lipophillic and fail to reach the market due to their poor water solubility. The solubility behavior of drug is the major challenge for formulation scientist. The present review is devoted to increase the solubility of poorly water-soluble drugs.
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