Volume 12 ; Issue 1 ; in Month : (2021) Article No : 113
Hussaini Sand Sayed S

Abstract

Angiotensin II receptor blockers provide better protection against stroke than Angiotensin converting enzyme inhibitors among the elderly population suffering from systolic hypertension. This research paper examines a series of published studies examining the superiority of angiotensin receptor blockers in stroke prophylaxis. The study designs identified during the research include clinical studies and systematic reviews. An evidence table was made to analyze the researched data. A thorough analysis was performed of the angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, and their mechanism of action as well as their pathophysiological effects. The results of the clinical trials demonstrated that angiotensin II receptor blockers indeed reduce stroke incidence in hypertensive patients. Angiotensin converting enzyme inhibitors were found to have no effect on stroke incidence, while two studies showed that they increased the incidence of stroke in hypertensives compared to a conventional anti-hypertensive therapy. After a head-to-head comparison of the two-drug regimen, with substantial clinical and experimental evidence supporting the research hypothesis, it can be concluded that angiotensin II receptor blockers are indeed a superior choice in stroke prophylaxis in the elderly population suffering from isolated systolic hypertension.

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