General Overview on Anti-epileptic Screening Models for Plant Molecules/Synthesized Molecules
Volume 10 ; Issue 1 ; in Month : June (2020) Article No : 101
Neha Tyagi, Santosh K Verma and Ajeet
This paper reviews model advances in epilepsy in recent years. Epilepsy is the commonest serious neurological condition, with a prevalence of 0.5–1% and Epilepsy is a chronic neurological condition characterized by recurrent seizures. Use of appropriate animal models is essential because epileptogenesis and seizure generation in temporal lobe epilepsy and other forms of epilepsy cannot be fully acquired in clinical studies with humans. Seizures are a combination of electrical and behavioral events that can induce chemical, molecular, and anatomic alterations. In this review, we summarize the most frequently used models of chronic epilepsy and models of acute seizures induced by electrical and chemical kindling. Kindling is animal models of epilepsy induced by electrical stimulation of the brain. Seizures are induced with minimal neuronal damage, which could greatly enhance our ability to define the basis for the initiation and remission of spontaneous seizure. Various animal models are also critical for elucidating the mechanisms underlying neurologic dysfunctions induced by developmental alcohol exposure and for uncovering the evolutionarily conserved mechanisms of epileptogenesis.
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